Cartilage Regeneration

Thursday, March 29, 2012

Myogenic Progenitors Impact Open but not Closed Bone Repair: Abstract and Introduction

posted by William Murrell Dubai Sports Doctor @ 8:58 AM  

2 Comments:

  • At March 29, 2012 at 8:58 AM , Blogger William Murrell Dubai Sports Doctor said...

    In summary, these studies show for the first time that a population or sub-population of myogenic progenitors of the MyoD-lineage can make a significant cellular contribution to bone repair. In a fracture repair setting, this required disruption of the periosteum and trauma to the local tissues. In a defect repair setting, this required direct access to the muscle. These data suggest that the recruitment of MyoD-lineage cells can be highly dependent on the nature and location of the bone injury. Even in the surgical mouse models with the greatest myogenic progenitor contribution, approximately half of the cells originated from non-myogenic lineages. Thus cell lineages other than myogenic cells including vascular cells are also likely to have a major role in bone formation and repair.[23]

    Apart from scientific clarification of the cellular contribution to bone repair in other orthopaedic models, future studies can aim to manipulate the surgical systems with the aim of maximizing MyoD-lineage cell access and mobilization to augment repair. Methods which optimize the contribution of secondary (non-periosteal) osteoprogenitors may be translatable to clinical practice and play a future role in improving the union rates of high energy and open fractures.

     

  • At March 29, 2012 at 1:03 PM , Blogger sagaworld said...

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